Doxycycline for community treatment of suspected COVID-19 in people at high risk of adverse outcomes in the UK (PRINCIPLE): a randomised, controlled, open-label, adaptive platform trial

Summary

Background

Doxycycline is often used for treating COVID-19 respiratory symptoms in the community despite an absence of evidence from clinical trials to support its use. We aimed to assess the efficacy of doxycycline to treat suspected COVID-19 in the community among people at high risk of adverse outcomes.

Methods

We did a national, open-label, multi-arm, adaptive platform randomised trial of interventions against COVID-19 in older people (PRINCIPLE) across primary care centres in the UK. We included people aged 65 years or older, or 50 years or older with comorbidities (weakened immune system, heart disease, hypertension, asthma or lung disease,

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Pedaling for Parkinson’s: CNY spin course fends off outcomes of disease (online video)

Liverpool, N.Y. — Every Monday, Wednesday and Friday, a modest team fulfills for a personal spin class in the again area of Pacific Well being Club.

All the biking students have Parkinson’s condition. They pedal to the beat of vintage tracks from the 1950s and ’60s, like “Lollipop” by The Chordettes or “Book of Love” by The Monotones. And sometimes, they sing together.

“Tell me, tell me, notify me,” sings Jerry Lotierzo, a retired guidance counselor and longtime activist. “Oh, who wrote the E book of Looooove?”

Lotierzo was identified with Parkinson’s illness when he was 76. He didn’t have

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